This year we celebrate the journal's 50 years of service to the field by reliving some of the most exciting and disappointing events in the last half-century of psychiatry. We begin in this issue with an overview by Jeffrey L. Geller, M.D., M.P.H., of the entire 50 years. In the February through November issues we will concentrate on important developments occurring during five-year periods. From each period, we will reprint an article that reflects a key development, with a commentary on the subsequent impact of the development and a Taking Issue column that presents a different, "Yes, but…" perspective. Finally, in December, we'll look at what's in store in the new millennium.