Also in the first chapter, psychiatric syndromes of limbic system dysfunction are divided in three groups: hypolimbic, hyperlimbic, and dysfunctional limbic syndromes. According to this scheme, primary and secondary depressive symptoms are associated with hypofunctioning of the orbitofrontal division, while lesions of the anterior cingulate above the corpus callosum produce profound apathy and akinesia. Amnesia is considered as hypofunctioning of the hippocampal-cingulate division. Similar associations for hyperlimbic syndromes are also discussed; they include mania, obsessive-compulsive symptomatology, interictal personality changes known as the Gastaut-Geschwind syndrome, and episodic explosive behavior. Dysfunction in the lateral orbitofrontal interactions is considered to be responsible for socially inappropriate behavior, while anxiety and panic disorders are related to dysfunction in integration of the visceral-amygdalar functions with the internal state of the organism.