Empirical studies of suicide pose unique methodological and ethical problems, as the internationally renowned contributors to this edited volume address. Self-inflicted death is a multidetermined and, fortunately, a relatively rare event. Multiple factors interact to determine the morbid outcome. These include but are not limited to age, gender, marital status, religion, culture, sexual orientation, genetics, medical and psychiatric illness, developmental history, medicinal and recreational drug use, life events, impulsivity, and social matrix. The nature of the event studied—suicide—is such that one cannot withhold a treatment, no matter how limited in impact from a selected vulnerable sample to ascertain whether a novel intervention may be more efficacious. It is not ethically permissible to put an at-risk group for self-inflicted death in a double-blind placebo-controlled trial—the gold standard of evidence-based medicine. We therefore must integrate findings from other research strategies with lesser degrees of scientific validity, such as meta-analyses, systematic reviews, cohort studies, case-control studies, cross-sectional surveys, and case reports.