In 1966, Charles Whitman, who was then a 25-year-old university student, shot and killed 16 people and wounded 32 from a rooftop, where he had gone, heavily armed, and opened fire until he was killed by police. The case became known as the case of the Texas Tower Sniper. In chapter 3 of The Origins of Antisocial Behavior, Giedd and colleagues describe this case as one that renewed discussion on brain pathology and violence. As revealed on autopsy, Whitman, it turned out, had a brain tumor affecting his amygdala, and many wondered whether it was the tumor that drove him to commit such an extreme act of violence. The chapter goes on to describe the amygdala and early studies of Kluver and Bucy, who described the phenomenology of lesions in the amygdalae of monkeys, including a lack of fear, hyperorality, and hypersexuality. The chapter also covers other noteworthy figures, such as Phineas P. Gage, who made infamous the notion that the prefrontal cortex plays a major role in mediating disinhibition, judgment, and decision making. The chapter highlights these tales to set the stage for subsequent discussion of specific brain regions and the latest data that address personality features of aggression, violence, and brain pathology. The third chapter of this book is only one of many that is full of rich information, laid out in a well-written and easily understandable format.