The DSM-5 cross-cutting symptom assessments and the World Health Organization Disability Assessment Schedule (WHODAS) represent efforts to “unpack” the elements of the axis V global score for users of DSM-5. These measures represent good targets for assessing treatment outcomes. They can be used across diagnostic categories, require no formal training, and have demonstrated reliability (4,5). The domains measured in the cross-cutting symptom assessments, such as depression, anxiety, sleep disturbance, somatic symptoms, suicidal ideation, and substance misuse, may be a part of the clinical presentation of virtually any patient, regardless of diagnosis. The WHODAS, based on the WHO International Classification of Functioning, Disability, and Health, is applicable across all health conditions. These are patient-completed instruments, although the assessment procedure used in the DSM-5 Field Trials specified clinical review and interpretation of patient responses.