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Articles   |    
Relationship Between Relapse and Hospitalization in First-Episode Psychosis
Donald Emile Addington, M.B.B.S.; Scott B. Patten, M.D., Ph.D.; Emily McKenzie, M.Sc.; Jean Addington, Ph.D.
Psychiatric Services 2013; doi: 10.1176/appi.ps.201200440
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The authors are affiliated with the Mathison Centre for Mental Health Research, Department of Psychiatry, University of Calgary, TRW Building, 3280 Hospital Dr. N.W., Calgary, Alberta T2N 4Z6, Canada (e-mail: addingto@ucalgary.ca).

Copyright © 2013 by the American Psychiatric Association


Objective  Relapse is a frequently used outcome measure in schizophrenia research. However, difficulties in reliably measuring relapse diminish its usefulness. Hospitalization is a potential alternative, but its relationship to relapse has not been assessed.

Methods  This study used data from a two-year, prospective study to examine associations between relapse and hospitalization in a cohort of 200 Canadian patients with first-episode psychosis. First, the relationship between relapse and hospitalization was assessed by cross-tabulating relapse and hospitalization. Next, survival curves of time to first relapse or hospitalization were compared. Finally, to examine the convergent validity of relapse and hospitalization, the predictive capacity of three predictors were examined: a substance use disorder diagnosis, prior hospitalization, and medication adherence.

Results  Rates of both relapse and hospitalization were similar. During the two-year follow-up, 37% of the patients experienced a relapse, and 26% were hospitalized. As an indicator of relapse, hospitalization had a low sensitivity (47%) and high specificity (87%). A higher risk of hospitalization and relapse was associated with prior hospitalization, a substance use disorder diagnosis, and medication nonadherence.

Conclusions  Results indicated that relapse and hospitalization are separate but related outcome measures. They had similar frequencies and were found to have similar relationships with some predictors. Relapse is a more useful outcome measure in smaller clinical studies in which routine standardized clinical measures can be used. Hospitalization is more relevant in larger studies or as a quality indicator for studies using administrative databases, and it serves as a good measure for quality management in health systems.

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Table 1Demographic characteristics of 200 patients with first-episode psychosis
Table Footer Note

a Includes common-law marriages. Data were missing on marital status and education for one patient.

Table Footer Note

b Includes homemakers and persons not in the labor force because of disability and retirement, as well as seven patients who reported self-employment



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