America's health care system has become too complex and costly to continue business as usual, according to a new report from the Institute of Medicine (IOM) that calls for a systemwide transformation. IOM analyses indicate that about 30% of health spending in 2009—more than $750 billion—was wasted on unnecessary services, inefficient delivery of care, excess administrative costs, inflated prices, prevention failures, and fraud. Inefficiencies have other costs: as many as 75,000 deaths might have been averted in 2005, according to research cited in the report, if every state had delivered care at the quality level of the best-performing state.