Stigma associated with mental illness has malignant effects on the lives of people with serious mental illnesses. Researchers have described two types—public stigma, or the prejudice and discrimination endorsed by the general population, and self-stigma, or the harm that occurs when a person internalizes this prejudice. Two articles in this month’s issue review a range of strategies used to combat stigma. In the lead article, Patrick W. Corrigan, Psy.D., and colleagues report on a meta-analysis of data from 72 outcome studies representing more than 38,000 research participants in 14 countries. Overall, strategies that include education about mental illness and contact with people who have mental illness are effective in reducing stigma. Contact appears to be more effective for adults, whereas education seems to work best among adolescents (page 963). In the second article, Dinesh Mittal, M.D., and coauthors report findings from a literature review of current research on self-stigma reduction. Two prominent approaches emerged: interventions that attempt to alter the individual’s stigmatizing beliefs and attitudes and interventions that enhance skills for coping with self-stigma through improvements in self-esteem, empowerment, and help seeking. The second approach seems to have gained traction among experts (page 974). In the Taking Issue commentary, Steven S. Sharfstein, M.D., encourages mental health professionals to improve their own attitudes “as we encounter our patients, in our use of language about individuals with mental illness and mental illness itself, and in communications among ourselves and with our patients” (page 953).