Participants' mean±SD age was 38±8 years, and time since HIV diagnosis was 11±5 years. Most participants were men (N=9, 69%), single (N=8, 62%), and white (N=8, 62%). Over half self-identified as heterosexual (N=7, 54%). Most had attained at least a high school education (N=10, 77%) and were employed (N=7, 54%). Three (23%) were unemployed, and three (23%) were disabled. All participants had a concurrent anxiety disorder, and three (23%) had a substance use disorder. Algorithm fidelity was 91% (proportion of algorithm-indicated medication changes communicated by the care manager to prescribers). The care manager completed 72% of phone contacts and 82% of in-clinic visits. Nine participants (69%) completed 12 weeks of depression treatment.