Diffusion of innovations is a challenge in health care. The learning collaborative is a well-established framework for spreading and adapting evidence-based treatments and creating change in organizations to improve care processes. Two reports in this issue describe large, successful learning collaboratives—one to promote integration of care and the other to disseminate supported employment. In the first study, Steven D. Vannoy, Ph.D., M.P.H., and colleagues used mixed methods to evaluate outcomes of a one-year learning collaborative focused on integration of services between community health centers (CHCs) and community mental health centers (CMHCs). The initiative brought together CHC-CMHC pairs to improve treatment of affective disorders in CHCs and improve care of patients at risk of metabolic syndrome at CMHCs. All pairs increased capacity on one or more patient health indicators, and participants' satisfaction with the collaborative process was high (page 753). In the Best Practices column, Deborah R. Becker, M.Ed., C.R.C., and colleagues describe the structure, operation, evolution, and outcomes of a national learning collaborative undertaken by the Johnson & Johnson-Dartmouth Program to disseminate individual placement and support, the evidence-based practice of supported employment for people with severe mental illnesses. The mental health and vocational rehabilitation leaders in 12 states and the District of Columbia have been able to expand services and achieve good outcomes during a period that has seen the erosion of psychosocial services nationwide (page 704).