Several of the chapters are especially beneficial to providers considering the complex interactions of a specific illness and its impact on the psychotropic treatment of patients. The chapter on gastrointestinal (GI) disorders, for example, discusses common disorders such as esophageal reflux and the potential indications for psychotropics, GI disorders on the interface of psychiatry (such as irritable bowel syndrome), GI side effects of psychotropic medications, and several important interactions. Special attention is given to patients with hepatic insufficiency, the pharmacologic impact of gastric bypass surgery, and antidepressant treatment issues with interferon-alpha hepatitis C treatment. The chapters on neurologic and endocrine disorders are equally superb. There is also an excellent discussion in the cardiology chapter on sudden death and QT prolongation due to psychotropic medications. Conversely, some of the chapters are a bit limited in the discussion of organ-specific illnesses, particularly the chapter on rheumatologic disorders.