We have begun work to adapt, pilot, evaluate, and disseminate a problem-solving intervention to prevent postnatal depression among mothers whose preterm infants are hospitalized in the neonatal intensive care unit (NICU). NICU stays are often prolonged, presenting an opportunity to implement a behavioral intervention when parents are assuming a primary caregiving role. In addition to preventing depression symptoms, our problem-solving education model aims to improve functioning, particularly in the domains of parent-child interaction, family dynamics, and child health care utilization.