Six articles in this issue report on studies that involved participants with depression or bipolar disorder. In a two-part article, a team of Veterans Affairs researchers describes the development of a collaborative care model for persons with bipolar disorder () and presents data on outcomes over three years for 306 veterans randomly assigned to the intervention or to usual care. The cost-neutral intervention significantly reduced the number of weeks spent in an affective episode (). An analysis of data for 1,531 participants in PRISM-E (Primary Care Research in Substance Abuse and Mental Health for the Elderly) found that depression outcomes at three and six months were similar for patients in two care models—an integrated model in which mental health services were co-located in primary care settings and a specialty referral model in which care was provided in a physically separate clinic (). Of the first 1,000 patients to enroll in STEP-BD (Systematic Treatment Enhancement Program for Bipolar Disorder), 248 were in a depressive phase at study entry. Among the 60 percent of this group who received any psychotherapy over the next year, those with severe symptoms benefited most (). Ten- to 15-year follow-up data are presented on use of mental health services by more than 300 individuals, nearly two-thirds of whom had a childhood diagnosis of major depression or an anxiety disorder. Compared with those who had no baseline mental disorders, participants with baseline depression were 13 times more likely to have received treatment in the follow-up period and those with anxiety disorders were six times more likely. Childhood anxiety was an especially strong predictor of later long-term treatment (). The nine-item depression module of the Patient Health Questionnaire was an effective means of detecting depression when used to screen more than 3,400 low-income patients at a primary care clinic serving Chinese Americans, a group known to underutilize mental health services (see ).