A central theme is that madness or mental illness occurs in all cultures; it assumes different meanings in different cultural contexts. For example, in medieval Europe, madness was thought to be related to demonic possession and witchcraft, and treatments necessarily followed the prescriptions provided by the church. With the advent of modern science, the scientific paradigm became the dominant cultural framework, and madness was related to genetic, biochemical, psychological, and sociocultural anomalies. The power of medications to correct "chemical imbalance" and the availability of new diagnostic tools to help unlock the mystery of the brain gave rise to the dominance of a disease-centered psychiatry.