Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Brief Reports   |    
Use of Augmentation Agents for Treating Depression: Analysis of a Psychiatric Electronic Medical Record Data Set
Kenneth R. Gersing, M.D.; John J. Sheehan, Ph.D.; Bruce Burchett, Ph.D.; Ling Zhu, Ph.D.; John A. Bates, Ph.D.; Ross A. Baker, Ph.D.; Iftekhar D. Kalsekar, Ph.D.
Psychiatric Services 2014; doi: 10.1176/appi.ps.201300288
View Author and Article Information

Dr. Gersing and Dr. Burchett are with the Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, North Carolina (e-mail: kenneth.gersing@duke.edu). When this work was done, Dr. Sheehan, Dr. Zhu, and Dr. Kalsekar were with Bristol-Myers Squibb, Plainsboro, New Jersey, where Dr. Bates is affiliated. Dr. Sheehan and Dr. Kalsekar are now with AstraZeneca, Fort Washington, Pennsylvania. Dr. Baker is with Otsuka Pharmaceutical Development and Commercialization, Inc., Princeton, New Jersey. The findings were presented at the annual meeting of the Academy of Managed Care Pharmacy, October 3–5, 2012, Cincinnati, Ohio.

Copyright © 2014 by the American Psychiatric Association

text A A A
PDF of the full text article.

Objective  This study evaluated the relationship between patient characteristics and augmentation strategies for the treatment of major depressive disorder.

Methods  This retrospective, cross-sectional study used data from a psychiatric electronic medical record database for patients with depression without psychosis or psychotic features who initiated augmentation therapy between January 2001 and June 2011. Medical records were evaluated to identify factors predicting use of specific augmentation agents, and a multivariate logistic regression model was used to assess clinical and demographic predictors of augmentation strategy.

Results  Of 3,209 patients initiating augmentation therapy for depression, 75% received augmentation with an antidepressant combination and 11% received augmentation with second-generation antipsychotics. Baseline clinical severity (Clinical Global Impressions–Severity score) most strongly and consistently predicted augmentation with second-generation antipsychotics.

Conclusions  Treatment of patients in specialty settings with depression was often augmented with an antidepressant combination, whereas those with severe depression had an increased likelihood of augmentation with second-generation antipsychotics.

Abstract Teaser
Figures in this Article

Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Related Content
DSM-5™ Clinical Cases > Chapter 3.  >
DSM-5™ Clinical Cases > Chapter 3.  >
DSM-5™ Clinical Cases > Chapter 16.  >
DSM-5™ Handbook of Differential Diagnosis > Chapter 2.  >
DSM-5™ Clinical Cases > Chapter 3.  >
Topic Collections
Psychiatric News
APA Guidelines
PubMed Articles